Antimicrobial Resistance
Helicobacter pylori lipid A phosphatase is required for polymyxin resistance
Published in Medical Letter on the CDC and FDA, August 13th, 2006
According to scientists writing in the Journal of Bacteriology, "Modification of the phosphate groups of lipid A with amine-containing substituents, such as phosphoethanolamine, reduces the overall net negative charge of Gram-negative bacterial lipopolysaccharide, thereby lowering its affinity to cationic antimicrobial peptides. Modification of the 1 position of Helicobacter pylori lipid A is a two-step process involving the removal of the 1-phosphate group by a lipid A phosphatase, LpxEHP (Hp0021), followed by the addition...
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