Drug Delivery
Supercritical fluid impregnation of indomethacin into chitosan provides controlled release
Published in Medical Letter on the CDC and FDA, August 13th, 2006
According to recent research from England, "Supercritical carbon dioxide (sc-CO2 ) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning electron microscopy (SEM)."
"The effects of the experimental temperature and pressure of the SC-CO2 on the thermal behavior of...
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