Ebola Virus
Reverse genetic generation of Ebola viruses attenuates virus growth
Published in Medical Letter on the CDC and FDA, August 20th, 2006
According to recent research from the United States, "The VP35 protein of Zaire Ebola virus is an essential component of the viral RNA polymerase complex and also functions to antagonize the cellular type I interferon (IFN) response by blocking activation of the transcription factor IRF-3. We previously mapped the IRF-3 inhibitory domain within the C terminus of VP35."
"In the present study, we show that...
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