Medical Letter on the CDC and FDA

Food Safety - Bovine biological fluid penicillin levels correlate with kidney tissue levels

HIV/AIDS Risk Factors - Depression and drug use do not account for STD and HIV epidemics in southern U.S.

HIV/AIDS Risk Factors - STD treatment can help identify people at risk for AIDS

Pneumococcal Vaccine - State vaccine financing policies affect uptake of pneumococcal conjugate vaccine

Streptococcal Infections - Immunohistochemical and molecular assays are used to diagnose streptococcal A infections

Addiction Medicine - Dopamine D₃ receptor antagonist blocks cocaine reward effects

Addiction Medicine - Early therapeutic alliance can help predict drug treatment dropout

Addiction Medicine - GABRA2 is linked to risk for conduct disorder and alcohol and drug dependence

Addiction Medicine - Toxicologic findings in suicide are presented in review

Alcohol Use - No link was found between striatal dopamine release and family history of alcoholism

Amyotrophic Lateral Sclerosis - CytRx successfully completes patient dosing and follow-up in Phase IIa clinical trial for ALS drug

Anal Fissure - Treatment of anal fissures is the focus of review

Antibiotic Resistance - Selection of ciprofloxacin resistance in Escherichia coli was investigated

Antimicrobial Resistance - Evidence for multidrug efflux pumps in Stenotrophomonas maltophilia was found

Attention Deficit Hyperactivity Disorder - P-glycoprotein has no apparent effect on pharmacodynamics of d-amphetamine

Attention Deficit Hyperactivity Disorder - Shire files NDA with U.S. FDA for compound to treat adult attention deficit disorder

Avian Influenza - Bird flu virus NS1 gene was progressively truncated after circulation in poultry

Avian Influenza - HepaLife continues bird flu vaccine development, discusses new report on influenza

Bacteriology - Conjugative Gram-positive Tn2009 in Gram-negative commensal bacteria has been reported

Behavioral Medicine - Factors affecting outcome of adoption of children from public care were examined

Bipolar Disorder Therapy - Ziprasidone is efficacious as bipolar disorder therapy

Breast Cancer - Tumor characteristics may provide prognostic information on breast cancer risk factors

Business Update - Bovie Medical reports U.S. FDA clears suture removal device for marketing

Business Update - EMD Chemicals gets U.S. FDA approval for Candurin for use in drugs

Business Update - Mylan announces final approval for added strengths of transdermal vasometer systems

Business Update - Sorin Group receives U.S. FDA approval to produce heart valves in Saluggia, Italy facility

Business Update - STERIS receives U.S. FDA market clearance for endoscope processing system

Cancer Gene Therapy - T cell receptor transduced into primary human lymphocytes

Cell Research - Reduced folate carrier is only system involved in folate uptake in intestinal epithelial cells

Dementia Therapy - Sugar and alcohol molecules are therapeutic for serpinopathies causing dementia and cirrhosis

Dengue Vaccine - Dengue 2 virus nonstructural glycoprotein NS1 was expressed in Pichia pastoris

Depression - Vagus nerve stimulation for treatment-resistant depression is focus of review

Diabetes Control - Novel program attempts to reduce lipid profile disparity among diabetes mellitus patients

Diabetes Healthcare - Hospital admission rates for low-income diabetes population depend on financial barrier to care

Diagnostics - 19-norandrosterone in athletes' urine usually indicates steroid use

Diagnostics - PreMD submits special 510(k) to U.S. Food and Drug Administration for handheld Prevu(x) Reader

Drug Abuse - Developmental behavior genetics of drug involvement are the focus of review

Drug Development - Bacterial racemases are potential targets for new antimicrobial agents

Drug Development - Strategies to improve plasma half-life of peptide drugs are reviewed

Drug Interactions - Model to optimize designs for CYP3A-mediated drug-drug interaction studies is developed

Eating Disorders - Pros and Cons of Eating Disorders scale is useful for treatment targeting

Endocrinology - Prepubertal children are especially sensitive to sex steroids

Epidemiology - Single data extraction generated more errors than double data extraction in systematic reviews

Finance - Immucor announces record fiscal fourth quarter revenues of $50M

Finance - Sciele Pharma, Inc. reports Q2 2006 revenues of $72.4 million, up 45% over Q2 2005

Finance - Spectranetics reports record Q2 2006 revenue of $16 million, up 50% over a year ago

Food Safety - Methods to enhance survival of bifidobacteria in milk have been developed

Fungal Infection - Preventing nephrotoxicity is important while treating invasive fungal infections

Gastric Cancer - No strong link found between human papillomavirus and gastric cancers

Gastroenterology - Adverse events from endoluminal therapies for gastroesophageal reflux disease are described

Gastroenterology - Impact of gastroesophageal reflux disease on work productivity is reviewed

Gastroenterology - Safety of agents for irritable bowel syndrome treatment is reviewed

Geriatrics - Thorough exam of elderly at admission to intermediate care units may improve outcomes

HIV/AIDS Therapy - Research leads to first treatment for drug-resistant HIV

HIV/AIDS Vaccine - HIV-neutralizing monoclonal antibody 4E10 recognizes N-terminal sequences on native antigen

Heart Failure - Abbott gets U.S. FDA clearance for test to diagnose congestive heart failure

Helicobacter Pylori - CagA status is important for successful eradication of Helicobacter pylori

Hepatitis B Virus - China immunizes millions of children against hepatitis B in historic collaboration

Inflammatory Bowel Disease - Isotretinoin is linked to inflammatory bowel disease

Influenza - MedImmune begins shipping live intranasal flu vaccine for 2006-2007 after U.S. FDA release

Influenza Vaccine - Computer model addresses pandemic influenza in 21st century

Influenza Vaccine - Lessons learned from the 2001-2004 Maryland influenza prevention seasons are presented

Influenza Vaccine - Vaccine redistribution model was developed to prevent influenza vaccine shortage

Irritable Bowel Syndrome - Efficacy of treatments for irritable bowel syndrome is focus of review

Lung Cancer - Lung cancer mortality possibly linked to exposure to chronic, low-levels of organic solvents

Malaria Pathogenesis - Plasma membrane permease is essential for purine salvage in Plasmodium falciparum

Malaria Therapy - Antifolates as therapy for Plasmodium falciparum infection are reviewed

Meibomianitis Therapy - Short-term oral minocycline treatment is efficacious for meibomianitis

Meningitis Therapy - Vancomycin-resistant Enterococcus faecium meningitis is reported