Antibiotics
Reports from the United States, Netherlands and Germany add new data to antibiotics research
Published in Medical Letter on the CDC and FDA, September 10th, 2006
Study 1: The lipid A 1-phosphatase of Helicobacter pylori is required for resistance to the antimicrobial peptide polymyxin.
According to scientists writing in the Journal of Bacteriology, "Modification of the phosphate groups of lipid A with amine-containing substituents, such as phosphoethanolamine, reduces the overall net negative charge of Gram-negative bacterial lipopolysaccharide, thereby lowering its affinity to cationic antimicrobial peptides. Modification of the 1 position of Helicobacter pylori lipid A is a two-step process...
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