Schistosomiasis Vaccine
Schistosoma mansoni tetraspanins protect against schistosomiasis
Published in Medical Letter on the CDC and FDA, September 17th, 2006
"Schistosomes are blood-dwelling flukes that infect 200 million people worldwide and are responsible for hundreds of thousands of deaths annually. Using a signal sequence trap, we cloned from Schistosoma mansoni two cDNAs, Sm-tsp-1 and Sm-tsp-2, encoding the tetraspanin (TSP) integral membrane proteins TSP-1 and TSP-2. We raised antibodies to recombinant TSP fusion proteins and showed that both proteins are exposed on the surface of S. mansoni," researchers in Australia report.
"Recombinant TSP-2, but not TSP-1, is strongly...
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