Neuroscience
Neuronal cell death rescued by restoration of receptor physiological levels
Published in Medical Letter on the CDC and FDA, September 17th, 2006
"Imbalances in neurotrophins or their high-affinity Trk receptors have long been reported in neurodegenerative diseases. However, a molecular link between these gene products and neuronal cell death has not been established," wrote S.G. Dorsey and colleagues, National Cancer Institute.
"In the trisomy 16 (Ts16) mouse there is increased apoptosis in the cortex, and hippocampal neurons undergo accelerated cell death that cannot be rescued by administration of brain-derived...
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