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Schizophrenia Therapy

Sertindole does not disrupt water maze performance

Published in Medical Letter on the CDC and FDA, October 8th, 2006

Sertindole, unlike clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment.

According to recent research from Denmark, "Cognitive deficits in schizophrenia are associated with poor functional outcome, and may be further aggravated by treatment with antipsychotics. In the present study the acute and chronic (three weeks of treatment) effects of clozapine, olanzapine, and sertindole on performance in the Morris water maze in rats was compared, using pharmacologically and/or clinically relevant dose regimens."

"An experimental design consisting of three trials/day over three days was used," said Michael...

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