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Leishmania

Researchers' work from Japan, Brazil and Iran adds to leishmania body of knowledge

Published in Medical Letter on the CDC and FDA, October 8th, 2006

Leishmania data are the focus of recent research from Japan, Brazil and Iran.

Study 1: Vaccination with a combination of Leishmania amastigote antigens and the lipid A analogue ONO-4007 helped prevent Leishmania amazonensis infection.

"Activation of innate immunity using adjuvants that activate Toll-like receptor 4 pathways have great potential for improving the protection induced by parasite vaccines. We investigated protective and therapeutic effects of a vaccine against leishmaniasis containing a combination of an adjuvant synthetic lipid A-analogue, ONO-4007 and Leishmania amazonensis antigens," investigators in Japan and...

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