Botulinum Toxin
Multiple-use botulinum A exotoxin remained sterile for more than seven weeks
Published in Medical Letter on the CDC and FDA, October 8th, 2006
"A preponderance of evidence now indicates that storage of reconstituted botulinum toxin solution for longer than the four hours recommended by the manufacturer does not result in loss of effectiveness. The purpose of this study was to assess whether serial re-extraction of reconstituted botulinum toxin solution from vials undergoing prolonged storage is associated with increased risk of microbial contamination," investigators in the United States report.
"Consecutive 100-U vials of botulinum A exotoxin were reconstituted with 2.5 mL each of normal saline with preservative...
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