Dialysis
Enoxaparin pharmacokinetics do not correlate with its effect in patients on dialysis
Published in Medical Letter on the CDC and FDA, October 8th, 2006
Researchers in the United States report, "The pharmacokinetics and pharmacodynamics of enoxaparin were studied in healthy volunteers and hemodialysis and peritoneal dialysis subjects. Antifactor Xa activity estimated the pharmacokinetics, whereas thrombin generation time (TGT) estimated the pharmacodynamics. Enoxaparin 1 mg/kg was given subcutaneously to all subjects."
"Antifactor Xa Amax and AUC0-12 were similar between groups, but the TGTmax was significantly greater in the dialysis groups...
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