Drug Delivery
In situ crosslinking by calcium leads to sigmoidal release from pectin matrix tablets
Published in Medical Letter on the CDC and FDA, October 8th, 2006
"Sigmoidal release pattern is therapeutically beneficial for timed release and colonic drug delivery, and is always observed in coated systems. In this study, sigmoidal release from pectin matrix tablets with indomethacin as a model drug was investigated," researchers in China report.
"The underlying mechanisms are calcium cation-induced in situ crosslinking that retard the initial drug release to a limited percentage. Power law equation n values were estimated for sigmoidal release profiles," said Xiuli Wei and colleagues at Fudan...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Medical Letter on the CDC and FDA
More Articles from Medical Letter on the CDC and FDA
- Antibacterial Agents
Intrapartum antibiotics prevent Escherichia coli infection only for term infants - Cancer Therapy
Antitumor responses are enhanced by B-cell depletion via decrease in IL-10 production - Cardiovascular Disease
Inhibition of rapamycin target modulates adhesion molecule expression - HIV/AIDS Epidemiology
HIV/AIDS epidemiology of adolescents and young adults in U.S. is reported - Rotavirus Vaccine
Restricting rotavirus vaccination schedule did not decrease risk of intussusception - Alcohol Use
Adolescent alcohol abuse and dependence are affected by parental factors - More from this issue of Medical Letter on the CDC and FDA
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
