Neuroblastoma
Neuroblastoma favorable prognosis linked to increased WSB1 copy number
Published in Medical Letter on the CDC and FDA, October 8th, 2006
"Gain of chromosome 17 is the most prevalent genetic abnormality identified in NB and distal 17q gain has prognostic significance in NB. In this report, we have combined array-based comparative genomic hybridization (A-CGH) and gene expression analysis to investigate gene copy number changes and its impact on the gene expression level as well as their association with prognosis genes located on chromosome 17 in NB tumors," researchers in the United States reported.
"We observed differential gains of chromosome 17 between Stages 4- and 4S tumors. We found that WSB1,...
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