Diabetes Model
Human insulin resistance is mimicked by O-GlcNAcase (oga-1) knockout in Caenorhabditis elegans
Published in Medical Letter on the CDC and FDA, October 15th, 2006
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "A dynamic cycle of O-linked N-acetylglucosamine (O-GlcNAc) addition and removal acts on nuclear pore proteins, transcription factors, and kinases to modulate cellular signaling cascades. Two highly conserved enzymes (O-GlcNAc transferase and O-GlcNAcase) catalyze the final steps in this nutrient-driven 'hexosamine-signaling pathway.' A single nucleotide polymorphism in the human O-GlcNAcase gene is linked to type 2...
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