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Vaccine Safety

Corticosteroids may reduce mortality in yellow fever vaccine-associated viscerotropic disease

Published in Medical Letter on the CDC and FDA, October 15th, 2006

Corticosteroid therapy may reduce mortality in yellow fever vaccine-associated viscerotropic disease.

According to a report from the United States, "During 1996 through 2004, 29 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) have been reported worldwide; 17 were fatal. Stress-dose corticosteroid (SDS) therapy has recently been found to improve survival among patients with septic shock but benefit for the treatment of YEL-AVD patients in septic shock is unknown."

"We retrospectively reviewed medical records of 11 U.S. YEL-AVD cases reported to the Vaccine Adverse Event Reporting System (VAERS) from 1996 through 2004," said...

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