Immunotherapy
Dendritic cell modulation by mast cells controls Th1/Th2 balance in responding T cells
Published in Medical Letter on the CDC and FDA, November 12th, 2006
According to a study from the United States, "The cytokines secreted by pathogen-activated human dendritic cells (DC) are strongly regulated in vitro by histamine, a major component of mast cell granules, ultimately modulating the capacity of the DC to polarize naive T cells. Because DC and mast cells are located in-close proximity in peripheral compartments, we hypothesized that mast cell products would influence the maturation of DC and hence the Th balance of an immune response in vivo."
"In this study, we show that specific mast cell degranulation stimuli,...
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