Prion Disease
Styrylbenzoazole derivatives are useful for treatment of transmissible spongiform encephalopathies
Published in Medical Letter on the CDC and FDA, November 19th, 2006
According to recent research from Japan, "Recent prevalence of acquired forms of transmissible spongiform encephalopathies (TSEs) has urged the development of early diagnostic measures as well as therapeutic interventions. To extend our previous findings on the value of amyloid imaging probes for these purposes, styrylbenzoazole derivatives with better permeability of blood-brain barrier (BBB) were developed and analyzed in this study."
"The new styrylbenzoazole compounds clearly labeled prion protein (PrP) plaques in brain specimens from human TSE...
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