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Addiction Medicine

US WorldMeds initiates phase 3 trial of lofexidine for treating opiate withdrawal symptoms

Published in Medical Letter on the CDC and FDA, December 3rd, 2006

US WorldMeds, a Kentucky-based specialty pharmaceutical company, announced that it is enrolling patients in a phase 3 clinical trial, USWM-001, investigating the use of lofexidine hydrochloride (lofexidine) for the treatment of opiate withdrawal symptoms in opiate dependent individuals.

If approved by the U.S. Food and Drug Administration (FDA), lofexidine would be the first non-addictive, non-narcotic treatment for relieving the distressing withdrawal symptoms associated with opiate detoxification approved in the United States.

Investigators are currently recruiting 264 patients to participate in the inpatient, randomized, double-blind trial that...

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