Plague Therapy

New findings from Tufts University, Center for Adaptation Genetics and Drug Resistance in the area of plague therapy described

Published in Medical Letter on the CDC and FDA, February 11th, 2007

Current study results from the report, "MarA-like regulator of multidrug resistance in Yersinia pestis," have been published. "MarA47(Yp) from Yersinia pestis, showing 47% identity to Escherichia coli MarA in its N terminus, caused resistance to antibiotics and to organic solvents when expressed in both E. coli and Y. pestis," researchers in the United States report.

"Resistance was linked to increased expression of the AcrAB multidrug efflux pump. In four of five spontaneous multidrug-resistant mutants of Y. pestis independently selected by growth on tetracycline, the marA47(Yp) gene was overexpressed," wrote R.A. Udani and colleagues, Tufts University,...

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Source: Medical Letter on the CDC and FDA (2007-02-11)

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