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Neurogenic Orthostatic Hypotension

Chelsea Therapeutics announces results of European Phase IIb trial of Droxidopa

Published in Medical Letter on the CDC and FDA, February 18th, 2007

Chelsea Therapeutics International, Ltd. (CHTP) reported the preliminary results of a European Phase IIb trial of Droxidopa, an orally available synthetic amino acid for the treatment of neurogenic orthostatic hypotension.

The primary objective of the trial was to determine the optimal dose of Droxidopa in the treatment of orthostatic hypotension in patients with multiple system atrophy (MSA) or Parkinson disease (PD). The double-blind, randomized, placebo-controlled, parallel group, Phase IIb trial, led by Christopher Mathias, DPhil, DSc, FRCP, professor of neurovascular medicine, Imperial College School of Medicine at St. Mary's Hospital, London, was conducted at 30...

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