Antipsychotics

Evidence lacking to support many off-label uses of atypical antipsychotics

Published in Medical Letter on the CDC and FDA, February 18th, 2007

Some newer antipsychotic medications approved to treat schizophrenia and bipolar disorder are being prescribed to millions of Americans for depression, dementia, and other psychiatric disorders without strong evidence that such off-label uses are effective, according to a new analysis by HHS' Agency for Healthcare Research and Quality.

The federally funded comparative effectiveness review of these drugs - called atypical antipsychotics - identified the medications' potential for serious side effects while pointing to an "urgent need" for more research into new treatments for the growing population of dementia patients who display severe agitation.

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Source: Medical Letter on the CDC and FDA (2007-02-18)

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