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Atherosclerosis Physiology

Research reports from University of Ottawa, Heart Institute provide new insights into atherosclerosis physiology

Published in Medical Letter on the CDC and FDA, March 11th, 2007

Current study results from the report, "NM23-H2, an estrogen receptor beta-associated protein, shows diminished expression with progression of atherosclerosis," have been published. According to recent research from Ottawa, Canada, "While estrogen receptor (ER) profile plays an important role in response to estrogens, receptor coregulators act as critical determinants of signaling. Although the clinical effects of ovarian hormones on various normal and pathological processes are an active area of research, the exact signaling effects on, for example, the vessel wall, are incompletely understood."

"Hence, we sought to discover proteins that associate with ERbeta, the...

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