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Biophysics

Research from Max Planck Institute for Biophysics, Department of Structural Biology provide new insights into biophysics

Published in Medical Letter on the CDC and FDA, March 11th, 2007

New investigation results, "Structure of GlnK1 with bound effectors indicates regulatory mechanism for ammonia uptake," are detailed in a study published in The EMBO Journal. According to recent research from Frankfurt am Main, Germany, "A binary complex of the ammonia channel Amt1 from Methanococcus jannaschii and its cognate P(II) signalling protein GlnK1 has been produced and characterized. Complex formation is prevented specifically by the effector molecules Mg-ATP and 2-ketoglutarate."

"Single-particle electron microscopy of the complex shows that GlnK1 binds on the cytoplasmic side of Amt1. Three high-resolution X-ray structures of GlnK1 indicate that the...

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