West Nile Virus Cell Biology
Research on west nile virus cell biology detailed by scientists at Washington University, Division of Infectious Diseases
Published in Medical Letter on the CDC and FDA, April 8th, 2007
New research, "Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis," is the subject of a report. "West Nile virus (WNV) is a neurotropic, arthropod-borne flavivirus that has become a significant global cause of viral encephalitis. To examine the mechanisms of WNV-induced neuronal death and the importance of apoptosis in pathogenesis, we evaluated the role of a key apoptotic regulator, caspase 3," scientists in the United States report.
"WNV infection induced caspase 3 activation and apoptosis in the brains of wild-type mice. Notably, congenic caspase 3(-/-) mice were more resistant to lethal WNV infection, although...
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