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Ulcerative Colitis

Lialda -- the first oral once-daily mesalamine for ulcerative colitis -- now available

Published in Medical Letter on the CDC and FDA, April 8th, 2007

Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announced the availability of Lialda (mesalamine) with MMXTM Technology, indicated for the induction of remission in patients with active, mild to moderate ulcerative colitis (UC), a type of inflammatory bowel disease. Lialda is the first and only FDA-approved once daily oral formulation of mesalamine. The U.S. Food and Drug Administration (FDA) approved Lialda on January 16, 2007.

Lialda is available to patients by prescription for oral administration in dosages of 2.4 g/day and 4.8 g/day, allowing patients to take as few as two tablets once daily. Other currently available mesalamines require three to four times daily...

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