Gene Therapy
Research from National Institute of Health Science broadens understanding of gene therapy
Published in Medical Letter on the CDC and FDA, May 6th, 2007
Researchers detail in "Cofilin plays a critical role in IL-8-dependent chemotaxis of neutrophilic HL-60 cells through changes in phosphorylation," new data in gene therapy. "Cofilin is a ubiquitous, actin-binding protein. Only unphosphorylated cofilin binds actin and severs or depolymerizes filamentous actin (F-actin), and the inactive form of cofilin is phosphorylated at Ser 3," scientists writing in the Journal of Leukocyte Biology report.
"We reported recently that cofilin plays a regulatory role in superoxide production and phagocytosis by leukocytes, and in the present study, we investigated the role of cofilin in the chemotaxis of neutrophilic HL-60 cells....
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