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Hemolytic Uremic Syndrome

Scientists at University of Munster detail research in hemolytic uremic syndrome

Published in Medical Letter on the CDC and FDA, September 9th, 2007

"Escherichia coli O157, of the H7 clone, exists in humans and in the environment as Shiga toxin ( Stx)-positive and Stx-negative variants. Stx production by infecting organisms is considered to be a critical requirement for the development of hemolytic uremic syndrome ( HUS), which occurs in similar to 15% of E. coli O157 infected patients," investigators in Munster, Germany report.

"It is unknown if loss of the stx gene during the early stage of an enterohemorrhagic E. coli infection prevents HUS, or if absence of the stx gene from E. coli O157 reduces or ablates virulence. We determined the frequency of stx-positive and stx-negative E. coli O157 isolates in stool...

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