Muscular Dystrophy

Research from Thomas Jefferson University yields new findings on muscular dystrophy

Published in Medical Letter on the CDC and FDA, September 9th, 2007

"Duchenne Muscular Dystrophy (DMD) is an incurable inherited disease of childhood, characterized by progressive muscle degeneration and weakness. Our previous findings supported the idea that dystrophin and associated proteins, absent or greatly reduced in DMD, are degraded in dystrophin - deficient muscle by the proteasomal - dependent pathway," scientists in the United States report.

"Indeed, treatment with the proteasome inhibitor MG - 132 of skeletal muscles from mdx mice - a spontaneous mouse model of DMD - as well as from DMD patients, effectively rescued the expression and correct cellular localization of dystrophin and associated proteins. These promising...

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Source: Medical Letter on the CDC and FDA (2007-09-09)

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