Bioinformatics

Data on bioinformatics published by researchers at USA Scientific

Published in Medical Letter on the CDC and FDA, September 23rd, 2007

"Protective antigen is essential for the pathology of Bacillus anthracis and is the proposed immunogen for an improved human anthrax vaccine. Known since discovery to comprise differentially charged isoforms, the cause of heterogeneity has eluded specific structural definition until now," researchers in the United States report.

"Recombinant protective antigen (rPA) contains similar isoforms that appear early in fermentation and are mostly removed through purification. By liquid chromatography-tandem mass spectrometry sequencing of the entire protein and inspection of spectral data for amino acid modifications, pharmaceutical rPA contained measurable deamidation at...

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Source: Medical Letter on the CDC and FDA (2007-09-23)

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