Gene Therapy

Studies from Department of Agriculture update current data on Gene Therapy

Published in Medical Letter on the CDC and FDA, September 30th, 2007

"The anaerobic spirochete Brachyspira hyodysenteriae is host to a bacteriophage-like agent known as VSH-1. VSH-1 is a novel gene transfer mechanism which does not self-propagate and transfers random 7.5 kb fragments of host DNA between B. hyodysenteriae cells," scientists in the United States report.

"In these investigations early events during VSH-1 induction by mitomycin C were examined. Quantitative PCR analysis revealed that VSH-1 hvp38 and hvp53 genes did not detectably increase in copy numbers during induction. Based on Northern blot hybridization assays, transcription of VSH-1 genes hvp38, hvp53, hvp45, hvp101, and lys increased fivefold to tenfold between 2 and...

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Source: Medical Letter on the CDC and FDA (2007-09-30)

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