West Nile Virus Genetics
Reports from Georgia State University, Department of Biology advance knowledge in west nile virus genetics
Published in Medical Letter on the CDC and FDA, October 14th, 2007
A report, 'Interaction between the cellular protein eEF1A and the 3'-terminal stem-loop of West Nile virus genomic RNA facilitates viral minus-strand RNA synthesis,' is newly published data in The Journal of Virology. "RNase footprinting and nitrocellulose filter binding assays were previously used to map one major and two minor binding sites for the cell protein eEF1A on the 3'(+) stem-loop (SL) RNA of West Nile virus (WNV) (3). Base substitutions in the major eEF1A binding site or adjacent areas of the 3'(+) SL were engineered into a WNV infectious clone," scientists in the United States report.
"Mutations that decreased, as well as ones that increased, eEF1A...
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