Endocrinology

New endocrinology research has been reported by scientists at Department of Agriculture

Published in Medical Letter on the CDC and FDA, October 28th, 2007

"'Life-threatening proinflammatory response (PR) induces severe GH resistance. Although low-level PR is much more commonly encountered clinically, relatively few studies have investigated the accompanying change in GH signal transduction progression and, in particular, the impact of low-level PR on Janus kinase (JAK)-2," investigators in the United States report.

"Using a low-level, in vivo endotoxin [lipopolysaccharide (LPS)] challenge protocol, we demonstrated that the liver tissue content of JAK2 declined 24 h (62%, P< 0.02) after LPS and that tyrosine- nitrated JAK2 could be immunoprecipitated from post-LPS liver biopsy homogenates. With antibodies developed to...

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Source: Medical Letter on the CDC and FDA (2007-10-28)

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