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DNA Vaccines

Findings from Oregon State University, Department of Pharmaceutical Sciences broaden understanding of DNA vaccines

Published in Medical Letter on the CDC and FDA, February 3rd, 2008

Research findings, 'Immunization by application of DNA vaccine onto a skin area wherein the hair follicles have been induced into anagen-onset stage,' are discussed in a new report. "An attractive approach to immunization is to apply DNA vaccine topically onto the skin. However, it is important to ensure that a strong immune response is induced without disrupting the skin stratum corneum," scientists in the United States report.

"The hair follicles have been shown to be the major portal of entry for DNA applied onto the skin, and it has been reported that the transfection of hair follicle cells occurs mainly at the onset of a new growing stage of the hair cycle. Using...

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