Adverse Drug Reactions

Studies conducted at Hospital for Sick Children on adverse drug reactions recently published

Published in Medical Letter on the CDC and FDA, April 20th, 2008

"Pemoline is a CNS stimulant that was introduced in 1975 in the US and was used to treat children with attention deficit hyperactivity disorder. Pemoline was withdrawn from the market 30 years later because of fatal hepatotoxicity associated with its use," researchers in Toronto, Canada report.

"To create a system that will estimate the potential association between a serious adverse event and a medication early in its marketing cycle. All case reports of acute liver failure associated with pemoline and reported to the US FDA from 1975 through 1999 were reviewed. All published articles on pemoline-induced hepatotoxicity were reviewed, and the Naranjo adverse drug...

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Source: Medical Letter on the CDC and FDA (2008-04-20)

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