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Lung Cancer Risk Factors
Data from Institute of Public Health, Department of Environmental Health advance knowledge in lung cancer risk factors
May 18th, 2008
Fresh data on lung cancer are presented in the report 'OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study.' "Oxidative DNA damage is believed to be implicated in lung carcinogenesis. 8-OxodG is a mutagenic and abundant oxidative modification induced in DNA. OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress," investigators in Copenhagen, Denmark report. "The polymorphism OGG1 Ser326Cys has in some studies been associated with risk of lung cancer. In a population-based cohort of 57,053 Danes, we examined associations between mRNA levels of...
Source: Medical Letter on the CDC & FDA (2008-05-18)
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