DOE/Brookhaven National Laboratory
Scientists determine drug target for the most potent botulinum neurotoxin
Published in Medical Letter on the CDC and FDA, June 1st, 2008
Botulinum neurotoxin – responsible for the deadly food poisoning disease botulism and for the beneficial effects of smoothing out facial wrinkles – can also be used as a dreaded biological weapon. When ingested or inhaled, less than a billionth of an ounce can cause muscle paralysis and eventual death. Although experimental vaccines administered prior to exposure can inhibit the destructive action of this neurotoxin – the most deadly protein known to humans – no effective pharmacological treatment exists.
Now, scientists at the U.S. Department of Energy's Brookhaven National Laboratory and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have...
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