Legionnaire Disease
Recent studies by Y. Belyi and co-authors add new data to legionnaire disease findings
Published in Medical Letter on the CDC and FDA, July 6th, 2008
"Legionella pneumophila is a facultative intracellular pathogen responsible for severe lung disease in humans, known as legionellosis or Legionnaires' disease. Previously, we reported on the similar to 60-kDa glucosyltransferase (Lgt1) from Legionella pneumophila, which modified eukaryotic elongation factor A. In the present study, using L. pneumophila Philadelphia-1, Lens, Paris, and Corby genome databases, we identified several genes coding for proteins with considerable sequence homology to Lgt1," scientists writing in the Journal of Bacteriology report.
"These new enzymes form three subfamilies, termed Lgt1 to -3, glucosylate mammalian elongation factor eEF1A...
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