Gene Therapy
Research from National Institute of Health Research, Division of Intramural Research provide new insights into gene therapy
Published in Medical Letter on the CDC and FDA, July 20th, 2008
Fresh data on gene are presented in the report 'NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway.' According to recent research from the United States, "In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1alpha, and COX-2. This response was dependent on the activation of the NF-kappaB signaling pathway."
"Farnesol treatment reduces the level of IkappaBalpha and induces translocation of p65/RelA to the nucleus,...
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