Fresh data on gene are presented in the report 'NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway.' According to recent research from the United States, "In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1alpha, and COX-2. This response was dependent on the activation of the NF-kappaB signaling pathway."
"Farnesol treatment reduces the level of IkappaBalpha and induces translocation of p65/RelA to the nucleus,...
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