Enzyme Research

Findings in enzyme research reported from University of Munich

Published in Medical Letter on the CDC and FDA, August 3rd, 2008

"Sulfur mustard (SM) is a strong vesicant that has been used as a chemical warfare agent. To understand the molecular mechanisms that underlie the inflammatory skin reaction in response to SM, we analyzed the activation pattern of the NF-kappa B and mitogen-activated protein kinase (MAPK) pathways," researchers in Munich, Germany report.

"Keratinocytes responded with an induction of the canonical NF-kappa B pathway, including activation of I kappa B kinase 2, followed by phosphorylation and degradation of I kappa B alpha and of the transactivating subunit RelA at Ser536. The biphasic NF-kappa B response was strictly dependent on the transactivating subunit RelA, as...

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Source: Medical Letter on the CDC and FDA (2008-08-03)

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