JAMA and Archives Journals

Changing dosing, administration of anthrax vaccine reduces side effects

Published in Medical Letter on the CDC and FDA, October 19th, 2008

Reducing the number of doses of an anthrax vaccine and changing its administration to intramuscular injection resulted in comparable measures of effectiveness but with fewer adverse events, according to a study in the October 1 issue of JAMA.

"Simpler and better tolerated regimens for vaccination with anthrax vaccine adsorbed (AVA) are needed," the authors write. The licensed AVA vaccination regimen is administered by injection below the skin (subcutaneously) at 0, 2, and 4 weeks and 6, 12 and 18 months, with annual boosters thereafter. Data supporting this regimen are limited.

The Centers for Disease Control and Prevention, Atlanta, in collaboration...

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Source: Medical Letter on the CDC and FDA (2008-10-19)

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