Medical Letter on the CDC & FDA
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Plague
Findings from University of Idaho advance knowledge in plague
November 9th, 2008
"Human polymorphonuclear leukocytes (PMNs, or neutrophils) are the primary innate host defense against invading bacterial pathogens. Neutrophils are rapidly recruited to sites of infection and ingest microorganisms through a process known as phagocytosis," researchers in the United States report. "Following phagocytosis by human PMNs, microorganisms are killed by reactive oxygen species (ROS) and microbicidal products contained within granules. Yersinia pestis, the causative agent of plague, is capable of rapid replication and dissemination from sites of infection in the host. Although Y. pestis survives in macrophages, the bacterial fate following interaction with...
Source: Medical Letter on the CDC & FDA (2008-11-09)
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