Medical Letter on the CDC & FDA
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West Nile Virus
Research from North Carolina State University broadens understanding of west nile virus
November 9th, 2008
According to recent research from the United States, "The innate immune response is the first line of defense against foreign pathogens. The recognition of virus-associated molecular patterns, including double- and single-stranded RNA, by pattern recognition receptors initiates a cascade of signaling reactions." "These result in the transcriptional upregullation and secretion of proinflammatory cytokines that induce an antiviral state. Many viruses have evolved mechanisms to antagonize these responses in order to help them establish a productive infection. We have previously shown that West Nile virus (WNV) is able to inhibit Toll-like receptor 3 (TLR3)-mediated...
Source: Medical Letter on the CDC & FDA (2008-11-09)
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