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West Nile Virus

Researchers from University of Hawaii, Medical Department report on findings in west nile virus

Published in Medical Letter on the CDC and FDA, November 9th, 2008

"Selenium ( Se) deficiency plays an important role in viral pathogenesis. To understand the effects of Se deficiency on West Nile virus (WNV) infection, we analyzed cytopathogenicity, apoptosis and viral replication kinetics, using a newly developed Se-deficient cell culture system," scientists in the United States report.

"Both Vero and SK-N-SH cells grown in Se-deficient media exhibited a gradual loss of glutathione peroxidase (GPx1) activity without any significant effect on cell growth and viability. In SK-N-SH cells, Se deficiency had no effect on the expression of key antioxidant enzymes, including manganese-and copper-zinc superoxide dismutase (MnSOD and...

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