Life Sciences

Research from D. Kumaran and co-authors reveals new findings on life sciences

Published in Medical Letter on the CDC and FDA, December 21st, 2008

"The seven antigenically distinct serotypes of Clostridium botulinum neurotoxins, the causative agents of botulism, block the neurotransmitter release by specifically cleaving one of the three SNARE proteins and induce flaccid paralysis. The Centers for Disease Control and Prevention (CDC)has declared them as Category A biowarfare agents," researchers in the United States report.

"The most potent among them, botulinum neurotoxin type A (BoNT/A), cleaves its substrate synaptosome-associated protein of 25 kDa (SNAP-25). An efficient drug for botulism can be developed only with the knowledge of interactions between the substrate and enzyme at the active site. Here, we...

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Source: Medical Letter on the CDC and FDA (2008-12-21)

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