West Nile Virus

Researchers from Washington University, Medical Department publish findings in west nile virus

Published in Medical Letter on the CDC and FDA, December 28th, 2008

"Protection against West Nile virus (WNV) infection requires rapid viral sensing and the generation of an interferon (IFN) response. Mice lacking IFN regulatory factor 3 (IRF- 3) show increased vulnerability to WNV infection with enhanced viral replication and blunted IFN-stimulated gene (ISG) responses," scientists in the United States report.

"IRF- 3 functions downstream of several viral sensors, including Toll-like receptor 3 (TLR3), RIG-I, and MDA5. Cell culture studies suggest that host recognizes WNV in part, through the cytoplasmic helicase RIG-I and to a lesser extent, MDA5, both of which activate ISG expression through IRF-3. However, the role of TLR3 in vivo...

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Source: Medical Letter on the CDC and FDA (2008-12-28)

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