Cancer Therapy
Reports from Wake Forest University, Comprehensive Cancer Center advance knowledge in cancer therapy
Published in Medical Letter on the CDC and FDA, January 11th, 2009
Research findings, 'Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death,' are discussed in a new report. "Fatty acid synthase (FASN) is the terminal enzyme responsible for fatty acid synthesis and is up-regulated in tumors of various origins to facilitate their growth and progression. Because of several reports linking the FASN and proteasome pathways, we asked whether FASN inhibitors could combine with bortezomib, the Food and Drug Administration-approved proteasome inhibitor, to amplify cell death," scientists in the United States report.
"Indeed, bortezomib treatment augmented...
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