Malaria
Reports outline malaria research from Mahidol University, Faculty of Tropical Medicine
Published in Medical Letter on the CDC and FDA, February 1st, 2009
New research, 'Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies,' is the subject of a report. According to a study from Bangkok, Thailand, "A bioanalytical method for the analysis of artesunate (ARS) and its metabolite dihydroartemisinin (DHA) in human plasma using protein precipitation and liquid chromatography coupled to positive tandem mass spectroscopy was developed. The method was validated according to published US FDA-guidelines and showed excellent performance."
"However, when it was applied to clinical pharmacokinetic studies in malaria, variable degradation of the artemisinins introduced an unacceptable large source of...
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