Emory University
Blocking toxic effects could make clot-buster safer
Published in Medical Letter on the CDC and FDA, February 15th, 2009
Scientists at Emory University School of Medicine are testing strategies for blocking LRP1, a molecule that appears to transmit inflammation signals triggered by tPA. They have found that in mice, genetically removing LRP1 from certain brain cells called microglia softens tPA's impact on the brain.
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