Legionnaire Disease

Findings from S. Urwyler et al in legionnaire disease reported

Published in Medical Letter on the CDC and FDA, March 8th, 2009

According to recent research published in the journal Traffic, "Legionella pneumophila, the causative agent of Legionnaires' disease, replicates in macrophages and amoebae within 'Legionella-containing vacuoles' (LCVs), which communicate with the early secretory pathway and the endoplasmic reticulum. Formation of LCVs requires the bacterial Icm/Dot type IV secretion system."

"The Icm/Dot-translocated effector protein SidC selectively anchors to LCVs by binding the host lipid phosphatidylinositol-4-phosphate (PtdIns(4) P). Here, we describe a novel and simple approach to purify intact vacuoles formed by L. pneumophila within Dictyostelium discoideum by using...

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Source: Medical Letter on the CDC and FDA (2009-03-08)

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