HIV/AIDS

Findings from L.M. Demeter et al in HIV/AIDS reported

Published in Medical Letter on the CDC and FDA, April 5th, 2009

"Whether therapeutic drug monitoring of protease inhibitors improves outcomes in HIV-infected patients is controversial. We evaluated this strategy in a randomized, open-label clinical trial, using a normalized inhibitory quotient (NIQ), which incorporates drug exposure and viral drug resistance," scientists in the United States report.

"NIQs <= 1 may predict poor outcome and identify patients who could benefit from dose escalation. Eligible patients had a viral load >1000 copies/ml on a failing regimen, and began a new protease inhibitor containing regimen at entry. All FDA-approved protease inhibitors available during the study recruitment (June 2002-May 2006)...

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Source: Medical Letter on the CDC and FDA (2009-04-05)

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